I'm always interested in trying new ways to save wear and tear on my delicate wrists; I'm currently giving the Evoluent Mouse-Friendly Keyboard and the Evoluent PostureRight Wrist Support a whirl.

The idea of the Mouse-Friendly Keyboard is that with standard keyboards, you usually have to reach too far to the right to get to your mouse; it's inconvenient and can stress your arm. With this one, the number pad's on the left, leaving room for the mouse on the right. (This is all fine assuming you're right-handed.) My problem is that the keyboard is several inches smaller (it's 15.4 inches wide) than the one I'm used to; I tend to prefer a more spacious layout for the keys. I could probably get used to it. The Mouse-Friendly would, however, make a really good travel keyboard; it's light and slim. And an attractive metallic-purple, I might add. 

Unequivocally, though, I love the wrist rest. It's extremely comfortable, with sloped indents for your wrists and a cushy gel filling. This one stays on my desk. 

You can get the keyboard for $64; the wrist support is $32.